Evidence map›Paper›PMID 41060069›Full record

ArticleJournal of bacteriology2025

Intracellular glutamine fluctuates with nitrogen availability and regulates

Elizabeth Varner, Mitchell Meyer, Jocelyn Whalen, Yu-Hao Wang, Carlos Rodriguez, Ifra Malik, Steven J Mullet, Stacy L Gelhaus, William H DePas

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Global Transcriptional Differences inAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Elizabeth Varner *Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0009-0005-6709-6208
Mitchell Meyer *Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6058-0738
Jocelyn Whalen *Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yu-Hao Wang *Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9673-8039
Carlos RodriguezDepartment of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ifra MalikDepartment of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Steven J MulletDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Stacy L GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9083-6933
William H DePasDepartment of Pediatrics, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8532-2567

Funding

The Impact of the Cystic Fibrosis infection environment on biofilm development of nontuberculous mycobacteriaR01AI170607 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William H. DePas · 2023 to 2026
$1.6M
An Exploris 240 for MetabolomicsS10OD032141 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2022 to 2022
$600k
Cystic Fibrosis Foundation BOMBER21R3National Institute of Allergy and Infectious Diseases R01-AI170607NIAID NIH HHS R01 AI170607NIH HHS S10 OD032141ODCDC CDC HHS S10-OD032141
6 · The paper itself

Abstract

Nontuberculous mycobacteria (NTM) can form biofilms during human infection and in household plumbing systems, so understanding biofilm regulation could help us better treat and prevent NTM infections. Glucose drives NTM aggregation

Indexed as

Bacterial ProteinsBiofilmsGlutamineMycobacterium smegmatisNitrogenAmmonium CompoundsBiosynthetic PathwaysDNA Transposable ElementsGene Expression Regulation, BacterialGlucoseHumansMutationMycobacterium abscessusMycobacterium Infections, NontuberculousAmmonium CompoundsBacterial ProteinsDNA Transposable ElementsGlucoseGlutamineNitrogenbiofilmsFlux-dependent sensorsnitrogen metabolismnontuberculous mycobacteriapurine metabolism

Identifiers

PMID41060069
PMCPMC12632254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.