Evidence map›Paper›PMID 41060027›Full record

ArticleJournal of virology2025

Mutations of two amino acids in VP5 mediate the attenuation of human rotavirus vaccine: evidence from

Theresa K Bessey, Yuhuan Wang, Sung-Sil Moon, Liliana Sanchez-Tacuba, Philippe H Jaïs, Harry B Greenberg, Baoming Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Theresa K BesseyDivision of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0002-2950-1365
Yuhuan WangDivision of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Sung-Sil MoonDivision of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
Liliana Sanchez-TacubaDepartment of Medicine and Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Philippe H JaïsEukarÿs SAS, Evry-Courcouronnes, France.
Harry B GreenbergDepartment of Medicine and Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Baoming JiangDivision of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0003-2072-0729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various vaccines, like polio, measles, and rotavirus, have been developed by serial-passaging in cell culture. Live oral rotavirus vaccines have been shown to be generally safe, but mechanisms of attenuation are not known. We have used a new, entirely plasmid-based reverse genetics system to artificially generate the novel human rotavirus vaccine strain CDC-9 (G1P[8]) and analyze the effect of the mutations within the VP4 gene on adaptation

Indexed as

Capsid ProteinsRotavirusRotavirus InfectionsRotavirus VaccinesAmino Acid SubstitutionAnimalsAnimals, NewbornChlorocebus aethiopsHumansMutationRatsVaccines, AttenuatedVero CellsVirus ReplicationVirus SheddingCapsid ProteinsRotavirus VaccinesVaccines, AttenuatedVP4 protein, Rotavirusin vitroin vivomutationsrotavirusvaccine

Identifiers

PMID41060027
PMCPMC12645992

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.