ArticleJNCI cancer spectrum2025
Comorbidity prevalence and incidence in cancer survivors: a longitudinal All of Us study.
Article in JNCI cancer spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Is endothelial dysfunction induced by aromatase inhibitors reversible after treatment?Breast cancer research and treatment · 2026Article
- Long-Term Risk of Pneumonia Among Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study.Cancers · 2025Article
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5 authors.
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Abstract
backgroundComorbidities worsen cancer survival, but patterns of preexisting and new-onset comorbidities among cancer survivors are unknown.
methodsWe investigated self-reported and clinically diagnosed comorbidity among cancer survivors in the All-of-Us program's national database. Eight highly prevalent comorbidities were identified using self-reported data from the personal health history survey among cancer survivors (n = 20 534) and noncancer adults (n = 113 628) and validated among cancer survivors (n = 26 978) using data from electronic health records (EHRs). Among 5-year survivors (n = 9174) documented in EHR, we further estimated the incidence of new-onset comorbidities.
resultsThe most prevalent comorbidities identified in personal health history data were hypertension (40.5%), osteoarthritis (28.4%), depression (28.0%), and obesity (23.2%). EHR data identified preexisting comorbidities: hypertension (43.3%), osteoarthritis (29.4%), depression (19.4%), and obesity (19.1%). During 5-year survival, more than 50% of cancer survivors developed at least one new comorbidity, and more than 25% developed two or more. The onset of new comorbidities showed a sharp increase in the first-year postdiagnosis. Incidence rates varied by age, race, and ethnicity.
conclusionFuture research is needed to develop effective strategies to prevent new-onset comorbidities during and after cancer treatment.
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