Evidence map›Paper›PMID 41059945›Full record

ArticleActa crystallographica. Section D, Structural biology2025

Reconstructing biological molecules with help from video gamers.

Andreas C Petrides, Robbie P Joosten, <it>Foldit</it> Players, Firas Khatib, Scott Horowitz

Abstract read
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Science and Videogames: From Scientific Dissemination to Knowledge Production.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andreas C PetridesDepartment of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, USA.
Robbie P JoostenOncode Institute and Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-2323-2686
<it>Foldit</it> PlayersUniversity of Denver, USA.
Firas KhatibDepartment of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, USA.ORCID 0000-0002-6817-7297
Scott HorowitzDepartment of Chemistry and Biochemistry and The Knoebel Institute for Healthy Aging, University of Denver, Denver, Colorado, USA.ORCID 0000-0002-1148-0105

Funding

HORIZON EUROPE Framework Programme 871037National Science Foundation 2051282National Science Foundation 2051305
6 · The paper itself

Abstract

Foldit is a citizen science video game in which players tackle a variety of complex biochemistry puzzles. Here, we describe a new series of puzzles in which Foldit players improve the accuracy of models in the public repository of experimental protein structure models, the Protein Data Bank (PDB). Analyzing the results of these puzzles showed that the Foldit players were able to considerably improve the deposited structures. We describe a mechanism by which the efforts of the Foldit players can be fed back into the structural biology scientific record by using Foldit results as improved input for the PDB-REDO databank. These efforts highlight the continued need for the engagement of the lay population in science.

Indexed as

ProteinsVideo GamesDatabases, ProteinModels, MolecularProtein ConformationProteinscitizen scienceFolditmodel curationPDB-REDO

Identifiers

PMID41059945
PMCPMC12576847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.