ReviewMemorias do Instituto Oswaldo Cruz2025
Role of the epitranscriptome in viral infections: beneficial or detrimental?
Review in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epitranscriptomics, the study of post-transcriptional chemical base modifications of RNAs, has become a crucial area of research for understanding the complex interactions between viruses and their hosts. These RNA modifications significantly impact both viral and host RNA functions, influencing viral replication, transcription, translation, and immune evasion. The advancement of high-throughput technologies, such as mass spectrometry-based techniques and next-generation sequencing, has enabled researchers to investigate epitranscriptomic modifications and their roles in gene regulation in greater depth. Viral RNAs often carry various epitranscriptomic modifications that facilitate their stability and translation, enabling viruses to hijack the host environment, enhance replication, and evade immune defences. Conversely, host epitranscriptomic modifications can enhance antiviral responses by regulating gene expression and promoting the degradation of viral RNAs. This dual role underscores the complexity of virus-host dynamics, where epitranscriptomic modifications can be both beneficial and detrimental. This review aims to provide an overview of current knowledge on epitranscriptomic modifications in viral infections, focusing on their roles in viral replication and immune interactions, while considering their potential as targets for antiviral therapeutic intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.