ArticleCytoskeleton (Hoboken, N.J.)2026
The New Nexin-Dynein Regulatory Complex Component CCDC153 Is Dispensable for Ciliary Motility and Fertility in Mice.
Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- The New Nexin-Dynein Regulatory Complex Component CCDC153 Is Dispensable for Ciliary Motility and Fertility in Mice.Cytoskeleton (Hoboken, N.J.) · 2026Article
- Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia.eLife · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The nexin-dynein regulatory complex (N-DRC) is an essential axonemal structure for ciliary and flagellar motility. Coiled-coil domain containing 153 (CCDC153) has recently been identified as a new N-DRC component in Tetrahymena thermophila. However, the physiological function of its mammalian homolog remains unknown. Here, we generated a Ccdc153 knockout mouse model and explored its functional association with motile cilia. We found that CCDC153 was highly expressed in the motile cilia-abundant tissues and localized to the axonemal lumen in motile cilia. However, Ccdc153 knockout mice were viable and exhibited normal brain ventricles and fertility. Overall, our results suggest that CCDC153 is dispensable for ciliary motility in brain ventricles and sperm movement, indicating that CCDC153 is not a potential causative gene in human ciliopathies.
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Registered trials
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