Evidence map›Paper›PMID 41059676›Full record

ReviewEuropean journal of clinical investigation2026

Cardiovascular biomarkers and preeclampsia: A narrative review.

Johana Ullmo, Madalina Nicoleta Nan, Mónica Cruz-Lemini, Carmen Garrido-Gimenez, Judit Platero, Álvaro García-Osuna, Pablo García-Manau, Marcel Twickler, Elisa Llurba

Abstract readReview
In one paragraph

Review in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Cardiovascular biomarkers and preeclampsia: A narrative review.European journal of clinical investigation · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johana UllmoDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Madalina Nicoleta NanDepartment of Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain.
Mónica Cruz-LeminiDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Carmen Garrido-GimenezDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Judit PlateroDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Álvaro García-OsunaDepartment of Clinical Biochemistry, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain.ORCID https://orcid.org/0000-0002-6682-0226
Pablo García-ManauDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Marcel TwicklerDepartment of Endocrinology, Diabetology and Metabolic Diseases AZ Monica, Antwerp/Deurne, Belgium.ORCID https://orcid.org/0000-0001-8738-207X
Elisa LlurbaDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-4048-6407

Funding

Instituto de Salud Carlos III JR19/00047Instituto de Salud Carlos III PT13/0002/0028Instituto de Salud Carlos III RD21/0012/0001Instituto de Salud Carlos III RD24/0013/0001;PI19/00702;PI22/00462;PI16/00375Recovery, Transformation and Resilience Plan 2017-2020, ISCIII, and by the European Union - Next Generation EU RD21/0012/0001
6 · The paper itself

Abstract

backgroundPreeclampsia is a disorder with complex pathophysiology, which underscores the need to study various biomarkers for its early prediction, accurate diagnosis, better understanding of underlying mechanisms and potential links to other diseases. A growing body of research has explored the potential of established and emerging cardiovascular biomarkers in the context of preeclampsia. The overlap in risk factors between preeclampsia and cardiovascular disease, along with findings from numerous epidemiological studies, suggests that cardiovascular biomarkers may play a key role in predicting preeclampsia, assessing its severity and determining the long-term risk of cardiovascular disease.

aimTo explore the role of cardiovascular biomarkers in the prediction, diagnosis and management of preeclampsia, while investigating their ability to improve insights into disease mechanisms and their connection to long-term cardiovascular risk. METHODS AND DISCUSSION: This review summarizes findings from existing research on cardiovascular biomarkers in preeclampsia, including studies examining their predictive and diagnostic capabilities, their role in elucidating disease pathophysiology, and their relevance for long-term cardiovascular risk assessment. Furthermore, it highlights emerging cardiovascular biomarkers, outlining their technical limitations and the need for further studies to clarify their utility in routine clinical practice.

conclusionCardiovascular biomarkers are becoming essential for diagnosing, monitoring and predicting outcomes in preeclampsia, enabling early detection and treatment. While some are already in clinical use, emerging biomarkers show promise for more precise and individualized care. Advancing research in this area offers significant potential to improve maternal and fetal outcomes.

Indexed as

Cardiovascular DiseasesPre-EclampsiaBiomarkersC-Reactive ProteinFemaleHeart Disease Risk FactorsHumansNatriuretic Peptide, BrainPregnancyBiomarkersC-Reactive ProteinNatriuretic Peptide, Braincardiovascular biomarkerscardiovascular diseaseNT‐proBNPPlGFpreeclampsiasFlt‐1

Identifiers

PMID41059676
PMCPMC12817246

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.