ArticleFrontiers in neurology2025
Elevated systemic immune-inflammation index is associated with stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Intravenous Thrombolysis Preceding Mechanical Thrombectomy in Patients with Acute Ischemic Stroke Reduces the Inflammatory Response: Preliminary Results Based on Retrospective Analysis of Medical Documentation.Journal of clinical medicine · 2026Article
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
- Systemic Inflammation Mediates the Association Between Admission Hyperglycemia and Pulmonary Infection or Prognosis in Acute Ischemic Stroke.Mediators of inflammation · 2026Article
- Elevated platelet-to-lymphocyte ratio is associated with stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Low hemoglobin-albumin-lymphocyte-platelet score as a risk marker for stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Multifaceted mechanisms of unconventional T cells in ischemia-reperfusion injury.Frontiers in immunology · 2026Review
- Article
- Association between systemic immune-inflammation index and in-hospital mortality in ICU patients with aspiration pneumonia: A retrospective cohort study based on MIMIC-IV database.Therapeutic advances in respiratory diseaseArticle
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5 authors.
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Abstract
Stroke-associated pneumonia (SAP) is a frequent complication of acute ischemic stroke (AIS) that contributes to poor clinical outcomes. The systemic immune-inflammation index (SII), derived from neutrophil, lymphocyte, and platelet counts, may reflect post-stroke immune imbalance, but its role in predicting SAP remains unclear. In this retrospective study, we analyzed 1,767 AIS patients and evaluated the association between log₂-transformed SII and the occurrence of SAP using multivariable logistic regression, generalized additive models, and two-piecewise regression. SAP developed in 21.3% of patients during hospitalization. Higher SII levels were independently associated with increased SAP risk after adjustment for age, sex, vascular risk factors, comorbidities, baseline National Institutes of Health Stroke Scale (NIHSS) score, and dysphagia assessed by Kubota Water Drinking Test (KWDT). Patients in the highest SII quartile had a significantly greater likelihood of developing SAP compared to those in the lowest quartile (adjusted odds ratio = 2.03, 95% confidence interval: 1.21-3.38,
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