ReviewFrontiers in neurology2025
The role of vagus nerve stimulation in modulating Parkinson's disease via the microbiota-gut-brain axis: a comprehensive review.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of transcutaneous auricular vagus nerve stimulation on motor and gait performance in Parkinson's disease: a meta-analysis of randomized controlled trials.Journal of neurology · 2026Pooled it
- Gastric-Selective Associations of Caudate Functional Connectivity with Gastrointestinal Rhythms in Parkinson's Disease: A Resting-State fMRI and Electrogastroenterography Study.Brain sciences · 2026Article
- GABA-Producing Bacteria as Potential Psychobiotics in Gut-Brain Axis Regulation.International journal of molecular sciences · 2026Review
- The gut microbiota-short-chain fatty acid-inflammation axis in Parkinson's disease motor dysfunction: mechanisms and future of dietary interventions.Frontiers in neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the global aging trend intensifies, the incidence of neurodegenerative diseases, including Parkinson's disease (PD), is increasing year by year. Currently, there is no effective cure for PD. Therefore, exploring safe and effective therapeutic targets is of utmost importance. Previous studies have shown that modulation of vagus nerve (VN) activity, a key communication pathway between the brain and the gut, may produce therapeutic effects in PD and influence its disease course by regulating the gut microbiota, brain plasticity, neuroimmune, and neuroendocrine systems, while the nerve itself also plays a complex role that can contribute to pathological processes like disease propagation. This review comprehensively summarizes the potential mechanisms by which vagus nerve stimulation (VNS) intervenes in PD may influence the microbiota-gut-brain axis (MGBA), including the regulation of gut microbiota composition and metabolites, inhibition of central and peripheral neuroinflammatory responses, modulation of hypothalamic-pituitary-adrenal (HPA) axis function, enhancement of brain region functional connectivity and neurotrophic factor secretion, and explores its potential value in translating into clinical therapeutic strategies. This study is the first to integrate the MGBA theory with VNS technology, revealing its cross-system regulatory network in intervening PD and providing new ideas for breaking through the limitations of traditional treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.