ArticleFrontiers in neurology2025
Pulse transit time respiratory swing as a diagnostic test for obstructive sleep apnoea in children-An observational study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulse transit time (PTT) has been identified as a potentially useful tool for diagnosing obstructive sleep apnoea (OSA) due to its high sensitivity in detecting cortical arousals. However, its use in clinical practise has been disappointing as it appears to lack the ability to distinguish between individuals with or without OSA. The majority of studies evaluating PTT for sleep-disordered breathing (SDB) have assessed the pulse transit time arousal index (PTT-AI), and there are limited published data on PTT respiratory swing (PTTrs). We previously conducted an observational study of PTT in 368 children with SDB. Our findings indicated that depending on the cut-off used, PTTrs identified OSA with low-to-moderate sensitivity and moderate-to-high specificity, using limited multi-channel sleep studies (MCSS) as the comparator. Methods: We conducted this cross-sectional observational study in another cohort of 1,031 children with SDB who attended a secondary care centre consecutively for MCSS between July 2022 and November 2024. Polysomnography (PSG) is not available in UK secondary care centres, and our use of MCSS in this setting is novel. We analysed the data of 629 children using multinomial regression and machine learning. Results: We found a stepwise increase in PTTrs with increasing severity of SDB. Children with mild OSA had a mean PTTrs of 20.7 ms. Machine learning analysis indicated that the oxygen desaturation index (ODI3) and PTTrs were the most important predictors of SDB amongst the 15 variables studied. Conclusion: Our findings suggest that PTTrs could complement oximetry to improve the detection of OSA in children. A validation study comparing PTTrs with PSG is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.