ArticleFrontiers in veterinary science2025
A newly discovered sRNA is involved in the virulence regulation of
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: A bacterial infection assay was conducted to detect the differential transcription levels of sRNA12 in the macrophage cell HD11. Environmental stress tests, intracellular survival assays, target gene transcription analyses and chick virulence tests were conducted to compare the wild-type strain and the ΔsRNA12 deletion strain. Results: A significant 7.5-fold increase in the transcription level of sRNA12 was observed during the invasion of host cells by bacteria. Under hyperosmotic conditions, the survival ability of the deletion strain was markedly reduced, while in a highly oxidative environment, it was significantly enhanced. Compared with the wild-type strain, the colonization ability of the ΔsRNA12 deletion strain in HD11 cells was enhanced by 3.5-fold. The transcription levels of most target genes of sRNA12, such as Conclusion: The findings suggest that the deletion of sRNA12 enhances the virulence of
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