ArticleJournal of global health economics and policy2025
Cost-effectiveness of respiratory syncytial virus prevention strategies in Mozambique: a modelling study.
Article in Journal of global health economics and policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cost-effectiveness of introducing a maternal vaccine or long-acting monoclonal antibody to prevent infant respiratory syncytial virus disease in Nepal.Journal of global health · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Background: Respiratory syncytial virus (RSV) is a leading cause of severe acute lower respiratory infections in children. The World Health Organization recently recommended two passive RSV immunisation strategies for global use, but prices are yet to be determined in low- and middle-income countries (LMICs). Methods: We used a static cohort model to generate preliminary estimates of the potential health impact and cost-effectiveness of a maternal vaccine (RSVPreF, Abrysvo Results: Year-round administration of a maternal vaccine (USD 5/dose, 69% efficacy, 87% coverage, 6 months protection) could cost USD 80 million and prevent 4,671 RSV deaths. Year-round administration of the long-acting infant mAb (USD 5/dose, 77% efficacy, 94% coverage, 5 months protection) could cost USD 85 million and prevent 5,128 RSV deaths. Over half the cost of the respective programs would be offset by healthcare cost savings. Compared to the current status quo, the cost per DALY averted from a government perspective was USD 288 (95% uncertainty interval 140-574) for the maternal vaccine and USD 289 (95% uncertainty interval 160-583) for the mAb. At an intervention price of USD 5 per dose, the probability is around 20% that either intervention is cost-effective at a threshold of 0.4 times the national GDP per capita. Conclusions: New passive immunisation interventions have the potential to prevent a substantial number of infant deaths in Mozambique. Both interventions have the potential to be cost-effective if priced below USD 5 per dose. A seasonal strategy could further improve cost-effectiveness if feasible to implement.
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