ArticleNorthern clinics of Istanbul2025
Hydroxytyrosol has a protective effect on the kidneys through dardarin and spexin.
Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Spexin Attenuates Cerebral Ischemia-Reperfusion-Induced Brain Injury in Rats via Suppression of NF-κB-Associated Inflammation and Apoptosis.Molecular neurobiology · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, the possible role of dardarin and spexin in the protective effect of hydroxytyrosol (HT) against corn syrup-induced renal injury in rats was investigated.
methodsRats were categorized into four groups (n=6) as control, HT, corn syrup, and corn syrup+HT. Over 6 weeks, rats were administered water infused with 30% corn syrup, 4 ml/kg/day solution containing HT was administered, both independently and in conjunction with corn syrup, throughout the 6 weeks. The molecular parameters of dardarin and spexin in the renal tissue were assessed through histopathological examination. Biochemical parameters were also examined with the ELISA Method.
resultsIn this study, it was observed that the dardarin and spexin levels increased in the control group as a result of the administration of corn syrup. After HT treatment, it was observed that the dardarin and spexin levels decreased. The increase in glucose, amylase, and lipase levels because of corn syrup consumption decreased with hydroxytyrosol consumption. The increase in erythrocyte extravasation, exudate accumulation, and fibrosis in kidney tissue observed as a result of corn syrup decreased as a result of HT administration.
conclusionIt is thought that the protective effect of HT against damage to the renal due to corn syrup consumption may be mediated by dardarin and spexin.
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