Evidence map›Paper›PMID 41059418›Full record

ArticleNorthern clinics of Istanbul2025

Toxic metals in rheumatological diseases: A systematic review.

Jozélio Freire de Carvalho, Thelma L Skare

Abstract read
In one paragraph

Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jozélio Freire de CarvalhoResearch Center for Chronic Non-Communicable Diseases (NUPEC), School of Nutrition, Federal University of Bahia, Salvador, Brazil.
Thelma L SkareDepartment of Rheumatology, Mackenzie Evangelical University Hospital, Curitiba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heavy metals exposure might be linked to rheumatic diseases and has been studied in a few articles. The aim of this article is to review the studies that evaluated metal toxicity in rheumatological diseases. A systematic search of PubMed, Embase, and Scielo databases was performed, looking for articles on toxic metals and rheumatic diseases published between 1966 and March 2023. A total of 31 studies (1,559 RA and 4,308 patients with other rheumatic diseases) were included. Most patients were females, ranging from 4 to 62 years old. Although most studies showed higher concentrations of toxic metals in rheumatic diseases, a few showed a positive association with disease activity or severity of the conditions. This systematic review reveals the presence of toxic metals in patients with rheumatic disease. Screening for toxic metals may be elucidative in selected cases.

Indexed as

metalsMetal toxicityrheumatic diseasesrheumatoid arthritis

Identifiers

PMID41059418
PMCPMC12497909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.