Evidence map›Paper›PMID 41059398›Full record

ArticleInfection and drug resistance2025

Optimizing Pediatric Sepsis Diagnosis: A Narrative Review of Two Decades of Evolution from SIRS to Phoenix Consensus.

Banga Mseza, Walyeldin Elfakey

Abstract read
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Banga MsezaDepartment of Pediatrics & Child Health, Faculty of Clinical Medicine & Dentistry, Kampala International University, Ishaka, Uganda.ORCID 0000-0002-7817-5252
Walyeldin ElfakeyDepartment of Pediatrics and Child Health, Faculty of Medicine, University of Bahri, Khartoum, Sudan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric sepsis definitions have evolved significantly from the 2005 International Pediatric Sepsis Consensus Conference (IPSCC) to the 2024 Phoenix Sepsis criteria. However, inconsistencies in previous models, including Systemic Inflammatory Response Syndrome (SIRS) and Sepsis-3, impacted diagnosis and treatment. A global task force conducted clinician surveys, meta-analysis, and validation studies, culminating in the Phoenix Sepsis Score as a refined diagnostic model. The Phoenix Sepsis Score assesses four organ systems, improving diagnostic accuracy and overcoming limitations seen in earlier models. This narrative review examines the evolution of pediatric sepsis definitions over the past two decades, from the 2005 International Pediatric Sepsis Consensus Conference (IPSCC) criteria to the recently published Phoenix Sepsis Score; providing a standardized and globally relevant approach to improving early detection and treatment outcomes.

Indexed as

pediatric sepsisPhoenix sepsis scoresepsis definitionsSIRS

Identifiers

PMID41059398
PMCPMC12497655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.