ArticleFrontiers in oncology2025
Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The impact of obesity on gene mutations in lung adenocarcinoma(ADC) remains unclear. This study investigates the association between Body Mass Index(BMI) and the gene mutation in ADC. Methods: This study investigated the relationship between BMI and ADC gene mutation. Logistic regression model was used to verify the association between BMI and ADC gene mutations. Threshold effect analysis is used to distinguish between linear and nonlinear. Subgroup analyses rigorously assessed demographic variations, significantly strengthening the study's credibility. Concurrently, the ROC curves were utilized to predict ADC gene mutation. Results: In our study, average ages of 66.00 Conclusion: This study reveals a significant association between BMI and ADC gene mutations, demonstrating that elevated BMI levels correlate negatively with mutation risk within the specific range of 21.08 to 22.86 kg/m². Furthermore, the rate of gene mutation may be relatively high in women under the age of 60 who do not smoke or drink. This study may assist clinicians in preliminarily assessing the gene mutation status of patients with ADC.
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