Evidence map›Paper›PMID 41059303›Full record

ArticleFrontiers in oncology2025

Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth.

Maria Fernandez, Rui Wang, Jingwei Wang, Shuai Wu, Kenneth Holder, Alia Nazarullah, Ricardo C T Aguiar, Zijun Y Xu-Monette, Ken H Young, Hui Yan and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Inhibition of RAB7 promotes CD8American journal of cancer research · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Maria Fernandez *Department of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Rui Wang *Department of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Jingwei WangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Shuai WuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Kenneth HolderDepartment of Pathology, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Alia NazarullahDepartment of Pathology, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Ricardo C T AguiarDepartment of Medicine, University of Texas Long School of Medicine, San Antonio, TX, United States.
Zijun Y Xu-MonetteHematopathology Division and Department of Pathology, Duke University Medical Center, Durham, NC, United States.
Ken H YoungHematopathology Division and Department of Pathology, Duke University Medical Center, Durham, NC, United States.
Hui YanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas at San Antonio, San Antonio, TX, United States.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Institutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1M
Intrinsic B cell epigenetic regulation of antibody and autoantibody responses by Sirt1R01AI105813 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2014 to 2023
$4.5M
Somatic hypermutation and class switching in autoimmunityR01AI079705 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2010 to 2019
$4.1M
IL-27-producing B cells in the antibody responseR01AI153506 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2021 to 2025
$2.2M
Oxidative stress and RNA methylationR01ES031522 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AGUIAR, RICARDO C · 2020 to 2024
$1.9M
Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptomeR01GM140456 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AGUIAR, RICARDO C · 2021 to 2024
$1.2M
FACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596k
Graduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and governmentT32AI138944 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2018 to 2022
$561k
Role of intracellular membrane signalosomes in B cell NF-kappaB activationR21AI131034 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2018 to 2019
$419k
Rab7 and NF-kappaB in B cell activation and dysregulationR21AI124172 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2016 to 2017
$413k
BLRD VA I01 BX001882BLRD VA IK6 BX006542NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI079705NIAID NIH HHS R01 AI105813NIAID NIH HHS R01 AI153506NIAID NIH HHS R21 AI124172NIAID NIH HHS R21 AI131034NIAID NIH HHS T32 AI138944NIDCR NIH HHS T32 DE014318NIEHS NIH HHS R01 ES031522NIGMS NIH HHS R01 GM140456NIH HHS S10 OD030432
6 · The paper itself

Abstract

RAB7, encoded by

Indexed as

B cell lymphomaBurkitt lymphomaCID1067700diffuse large B-cell lymphomaFX1MβCDNF-κBRAB7

Identifiers

PMID41059303
PMCPMC12497597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.