Evidence map›Paper›PMID 41059283›Full record

ArticleJournal of inflammation research2025

Low-Intensity Pulsed Ultrasound Promotes a Treg-Like Phenotype and Suppresses a Th17-Like Phenotype in CD4

Renli Yang, Xirui Zhang, Yanjun Zhang, Yi Man, Xingmei Yang

Abstract read
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Renli YangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Jinjiang Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Xirui ZhangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Yanjun ZhangDepartment of Stomatology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, People's Republic of China.
Yi ManState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Xingmei YangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.ORCID 0000-0003-4286-8767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: CD4 Methods: CD4 Results: LIPUS treatment significantly increased the frequency of Foxp3-expressing cells while decreasing the frequency of IL-17A-producing cells. Additionally, LIPUS promoted the activation and nuclear translocation of YAP and TAZ, as evidenced by enhanced protein expression and a shift in subcellular localization. siRNA-mediated knockdown of YAP/TAZ attenuated the LIPUS-induced increase in Foxp3 Discussion: Our findings demonstrate that LIPUS promotes a Treg-like phenotype and suppresses a Th17-like phenotype in CD4

Indexed as

low-intensity pulsed ultrasoundTAZTh17TregYAP

Identifiers

PMID41059283
PMCPMC12499271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.