Evidence map›Paper›PMID 41059267›Full record

ArticleJAC-antimicrobial resistance2025

Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study.

Daniele Roberto Giacobbe, Claudia Bartalucci, Martina Bavastro, Riccardo Schiavoni, Vincenzo Di Pilato, Marco Muccio, Alessio Signori, Chiara Aldieri, Jacopo Angelini, Erika Asperges and 54 more

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Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Daniele Roberto GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0003-2385-1759
Claudia BartalucciDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Martina BavastroDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Riccardo SchiavoniDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Vincenzo Di PilatoDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-5863-5805
Marco MuccioClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alessio SignoriSection of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Chiara AldieriInfectious Diseases Unit, Santa Croce e Carle Hospital, Cuneo, Italy.
Jacopo AngeliniDepartment of Medicine (DMED), University of Udine, Udine, Italy.
Erika AspergesDepartment of Diagnostic, Paediatric, Clinical and Surgical Sciences, University of Pavia, Pavia, Italy.
Elisabetta Blasi VaccaSC Malattie Infettive, EO Galliera, Genova, Italy.
Nicoletta BoffaUOC Anestesia e Rianimazione, ASL 4 Veneto Orientale, San Donà di Piave, Italy.
Enrica BonoSC Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Bruno CacopardoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Alessandra CalabresiAOU 'SS Antonio, Biagio e Cesare Arrigo', Alessandria, Italy.
Martina CasariniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Annamaria CattelanInfectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy.
Silvia CorcioneInfectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy.
Federica CosentinoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Gennaro De PascaleDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco Giuseppe De RosaInfectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0001-8338-0130
Valerio Del BonoInfectious Diseases Unit, Santa Croce e Carle Hospital, Cuneo, Italy.
Filippo Del PuenteSC Malattie Infettive, EO Galliera, Genova, Italy.
Chiara FanelliDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Fiorenza FavaAnestesia e Terapia Intensiva Cardiotoracica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Erica FranceschiniInfectious Diseases Unit, Azienda Ospedaliera-Universitaria of Modena, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0001-6922-5759
Nicholas GeremiaUnit of Infectious Diseases, Department of Clinical Medicine, Ospedale 'Dell'Angelo', Venice, Italy.
Maddalena GiannellaDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Simone GiulianoInfectious Diseases Clinic, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Ivana MaidaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Andrea MarinoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-5650-6911
Maria MazzitelliInfectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy.ORCID https://orcid.org/0000-0003-0263-0703
Maria Chiara MeloniDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Marco MerliInfectious Diseases Clinic, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.ORCID https://orcid.org/0000-0001-5081-8669
Marianna MeschiariInfectious Diseases Unit, Azienda Ospedaliera-Universitaria of Modena, University of Modena and Reggio Emilia, Modena, Italy.
Chiara MorealDepartment of Medicine (DMED), University of Udine, Udine, Italy.
Chiara OltoliniInfectious Diseases Clinic, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Rita PalloneDepartment of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Sandro PaneseUnit of Infectious Diseases, Department of Clinical Medicine, Ospedale 'Dell'Angelo', Venice, Italy.
Emanuele PontaliSC Malattie Infettive, EO Galliera, Genova, Italy.
Martina RicciardettoInfectious Diseases Unit, Azienda Ospedaliera-Universitaria of Modena, University of Modena and Reggio Emilia, Modena, Italy.
Matteo RinaldiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Alessandro RussoDepartment of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Maurizio SanguinettiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0002-9780-7059
Vincenzo ScaglioneInfectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy.
Francesca SerapideDepartment of Medical and Surgical Sciences, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.
Francesco Saverio SerinoUOC Medicina, ASL 4 Veneto Orientale, Portogruaro, Italy.
Nour ShbakloInfectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy.
Carlo TortiDipartimento di Scienze Mediche e Chirurgiche, UOC Malattie Infettive, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Giovanna TraviInfectious Diseases Clinic, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Laura MagnascoClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID https://orcid.org/0000-0002-6343-3271
Federica PortunatoClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Federica BrianoClinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Malgorzata MikulskaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0002-5535-4602
Lorenzo BallDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Chiara RobbaDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0003-1628-3845
Nicolò PatronitiDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Denise BattagliniDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Mauro GiacominiDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Genoa, Italy.
Erika CoppoUO Microbiologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Anna MarcheseDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Antonio VenaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
ISA-SITA investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes. Methods: Prospective, observational study of ICU patients treated with isavuconazole from January 2023 to 30 April 2025 in 17 centres (ISA-SITA study within the MULTI-SITA project). Results: A total of 177 ICU patients treated with isavuconazole were included in the study. Most patients showed at least one European Organisation for Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) or FUNgal Diseases in adult patients in Intensive Care Unit (FUNDICU) host factor (141/177, 79.7%). Overall, 82/177 patients (46.3%) had either proven or probable invasive mould disease (6 and 76, respectively, mostly invasive pulmonary aspergillosis). In patients with proven or probable disease, 30-day mortality was 44.0%, and 90-day mortality was 62.2%. In multivariable analyses, SOFA score (HR 1.14 per one point increase, 95% CI 1.03-1.26, Conclusions: Diverse patterns of isavuconazole use were observed in a large cohort of critically ill adult patients, and the drug was well tolerated. Mortality was lower than many previous estimates in critically ill patients and could serve as a basis for future standardized comparisons.

Identifiers

PMID41059267
PMCPMC12498522

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