Evidence map›Paper›PMID 41059251›Full record

ArticleRadiology advances2025

Fetal MRI deep learning segmentation of body and lung in congenital diaphragmatic hernia.

Leon M Bischoff, Sebastian Nowak, Maximilian Mader, Maike Theis, Thomas Vollbrecht, Alexander Isaak, Daniel Kuetting, Claus C Pieper, Annegret Geipel, Florian Kipfmueller and 3 more

Abstract read
In one paragraph

Article in Radiology advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leon M BischoffDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0001-5193-5226
Sebastian NowakDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0001-5175-5559
Maximilian MaderDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.
Maike TheisDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0003-2666-9928
Thomas VollbrechtDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0002-1162-2839
Alexander IsaakDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0003-2016-6166
Daniel KuettingDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0001-6520-1020
Claus C PieperDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.
Annegret GeipelDepartment of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, NRW, 53127, Germany.
Florian KipfmuellerDepartment of Neonatology and Pediatric Critical Care Medicine, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0002-7414-757X
Brigitte StrizekDepartment of Obstetrics and Prenatal Medicine, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0003-3625-7097
Alois M SprinkartDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.ORCID https://orcid.org/0000-0002-1435-9562
Julian A LuetkensDepartment of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, NRW, 53127, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine if deep learning (DL) segmentation of total fetal body volume (TFBV) and total fetal lung volume (TFLV) in fetuses with congenital diaphragmatic hernia has comparable performance to manual segmentation. Materials and Methods: A total of 208 fetal MRI studies with congenital diaphragmatic hernia, acquired between August 2007 and September 2023, were retrospectively included. TFBV and TFLV were extracted from manual tissue segmentations in balanced gradient echo and single shot T2-weighted turbo spin echo sequences. MRI studies were split into training (n = 188) and hold-out test data (n = 20). Wilcoxon signed-rank test was used to compare manual and DL-based segmentations by 2 U-Nets. Manual and DL segmentation times were noted and compared using Student's t-test. The observed/expected ratio of the total lung volume (O/E TLV) as a prognostic marker for postnatal survival was calculated. Outcome predictions of O/E TLV for postnatal death were assessed with univariate regression analysis. Results: Manual segmentation times were higher compared to DL segmentations (30 ± 7 minutes versus 0.25 ± 0.05 minutes, Conclusion: DL for body and lung segmentation in fetuses with congenital diaphragmatic hernia allows reliable and rapid calculations of the observed/expected ratio and equally predicts prognostic outcome.

Indexed as

congenital diaphragmatic hernia (CDH)fetalmagnetic resonance imaging (MRI)nnU-Netprognosis

Identifiers

PMID41059251
PMCPMC12429181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.