Evidence map›Paper›PMID 41059232›Full record

ArticleFrontiers in endocrinology2025

The association between gestational hypothyroidism in pregnant women with preeclampsia, maternal liver function indicators, and neonatal birth weight: a study in Chinese pregnant women.

Fang Zhang, Qing Hua, Xiaoyan You, Fenglian Shi, Yadan Zhou, Xia Xu, Xiaona Tian, Gang Tian, Li Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fang Zhang *Department of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Qing Hua *Department of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Xiaoyan YouDepartment of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Fenglian ShiDepartment of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Yadan ZhouDepartment of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Xia XuInstitute of Trauma and Metabolism, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Xiaona TianDepartment of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Gang TianHenan Province Hypertension Precision Prevention and Control Engineering Research Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Li LiDepartment of Obstetrics, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Birth weight serves as a critical indicator of neonatal survival. Preeclampsia represents a serious complication during pregnancy and is closely associated with gestational hypothyroidism (GHT), both of which severely affect neonatal birth weight. Preeclampsia and hypothyroidism during pregnancy are usually accompanied by abnormalities of maternal liver function, which frequently leads to adverse pregnancy outcomes including low birth weight (LBW). This retrospective study utilized data from 420 cases of patients with preeclampsia who underwent prenatal examinations and delivery at department of Obstetrics. The association between preeclampsia combined with GHT in pregnancy, maternal liver function and neonatal birth weight was estimated using generalized linear model (GLM), and the potential partial mediating effects of maternal liver function were assessed through mediating models. Among pregnant women with preeclampsia, 11.0% had GHT, and the median (interquartile range) birth weight of all neonates was 2990.0 (2541.3, 3368.8) grams. Neonates born to pregnant women who had preeclampsia combine with GHT showed a higher incidence of LBW (

Indexed as

Birth WeightHypothyroidismLiverPre-EclampsiaPregnancy ComplicationsAdultChinaEast Asian PeopleFemaleHumansInfant, Low Birth WeightInfant, NewbornLiver Function TestsPregnancyPregnancy OutcomeRetrospective Studiesbirth weightgestational hypothyroidismliver functionmediating modelpreeclampsia

Identifiers

PMID41059232
PMCPMC12498002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.