Evidence map›Paper›PMID 41059222›Full record

ArticleFrontiers in endocrinology2025

Alterations in peripheral CD4

Reiko Saito, Jun Hirakawa, Mami Kuwamura, Takayuki Hoshina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. T cell dysregulation and remodeling in pediatric obesity and weight loss.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Reiko Saito *Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Jun Hirakawa *Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mami KuwamuraDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Takayuki HoshinaDepartment of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Childhood obesity may elevate the risk for adult obesity because of chronic inflammation and immune dysregulation; however, studies on the immune system in obese children are limited. This study aimed to investigate peripheral blood lymphocyte subpopulations in obese children and their association with metabolic markers. Methods: This prospective study included 30 obese children (median age: 11.5 years) and 22 age-matched non-obese controls. Lymphocyte populations were compared between the two groups. Additionally, factors influencing these populations were assessed in the obese group. Results: The proportion of CD4 Conclusions: This study highlights the impact of childhood obesity on immune dysregulation. The changes in T cell subpopulations in obese children differ from those observed in obese adults and vary depend on the duration of obesity.

Indexed as

BiomarkersCD4-Positive T-LymphocytesPediatric ObesityT-Lymphocyte SubsetsAdolescentCase-Control StudiesChildFemaleHumansMaleProspective StudiesT-Lymphocytes, RegulatoryBiomarkersCD4+ T cellschildhood obesityimmune dysregulationinsulin resistancelymphocyte subpopulationsmetabolic dysfunctionregulatory T cells

Identifiers

PMID41059222
PMCPMC12497623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.