Evidence map›Paper›PMID 41059211›Full record

ArticleFrontiers in oral health2025

Signs and symptoms of oral candidiasis associated with health factors and resistant

Karolina M Czajka, Chris P Verschoor, Stacey A Santi, Danielle Brabant-Kirwan, Meredith H Kusnierczyk, Krishnan Venkataraman, Vasu D Appanna, Ravi Singh, Sujeenthar Tharmalingam, Deborah P Saunders

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nucleic Acid Amplification Tests forPathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karolina M CzajkaMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Chris P VerschoorMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Stacey A SantiHealth Sciences North Research Institute, Sudbury, ON, Canada.
Danielle Brabant-KirwanHealth Sciences North Research Institute, Sudbury, ON, Canada.
Meredith H KusnierczykHealth Sciences North Research Institute, Sudbury, ON, Canada.
Krishnan VenkataramanMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Vasu D AppannaSchool of Natural Sciences, Laurentian University, Sudbury, ON, Canada.
Ravi SinghMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Sujeenthar TharmalingamMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Deborah P SaundersMedical Sciences Division, Northern Ontario School of Medicine University, Sudbury, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral candidiasis is a common fungal infection that disproportionately affects older adults, immunosuppressed individuals, and patients undergoing cancer treatment. Despite its prevalence, diagnosis and treatment remain challenging due to the diverse symptom presentation and potential for antifungal resistance. Objective: This study aimed to systematically evaluate which clinical signs and symptoms are most predictive of oral Methods: A cohort of 57 patients aged 65 years and older (mean age 74) was enrolled through oncology and hospitalist clinics in Northern Ontario. The majority (65%) were actively receiving cancer treatment. Participants underwent clinical assessment for oral candidiasis signs and symptoms, and fungal swabs were taken at baseline and two-week follow-up. Fungal species identification and treatment outcomes were recorded. Results: The majority of infections involved Conclusion: These findings underscore the clinical variability of oral candidiasis and highlight the need for rapid molecular diagnostic tools at the point of care to distinguish infection types and guide appropriate therapy, particularly in older and medically complex populations.

Indexed as

antifungal resistanceCandida albicanserythematous candidiasisNakaseomyces glabratusolder adultsoral candidiasisPichia kudriavzeviipseudomembranous candidiasis

Identifiers

PMID41059211
PMCPMC12498526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.