ArticleRadiology advances2025
Intervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography.
Article in Radiology advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Feasibility of multifrequency MR elastography of the seminal vesicles in healthy men, benign prostatic hyperplasia, and prostate cancer.European radiology experimental · 2026Article
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Assessment of intervertebral disc (IVD) degeneration on conventional magnetic resonance imaging (MRI) is limited by large inter-reader variability and lack of stratification in clinical trials and their assessment of treatment responses. Therefore, we aimed to introduce and diagnostically validate multifrequency magnetic resonance elastography (MRE) with tomoelastography processing for the assessment of lumbar IVD degeneration in healthy volunteers and patients with low back pain. Methods: In this prospective single-center study, 60 participants (30 volunteers without low back pain and 30 patients with low back pain, 41 ± 17 years, body mass index 23.9 ± 3.7 kg/m Results: Area under the receiver operating characteristic curve (AUC) analysis showed good diagnostic performance for detecting IVD degeneration (Pfirrmann score I/II/III/IV/V with Discussion: Multifrequency MRE with tomoelastography processing allows effective IVD assessment and shows promise as a quantitative clinical imaging modality for assessing IVD degeneration.
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