ArticleRadiology advances2024
CT trachea surface roughness is associated with chronic obstructive pulmonary disease symptoms.
Article in Radiology advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Trachea structural abnormalities occur in patients with chronic obstructive pulmonary disease (COPD), yet there are few methods for quantifying trachea surface topology. Purpose: To develop a method to quantify trachea surface roughness on CT imaging and investigate the association with airflow limitation and symptoms in COPD. Materials and Methods: Participants from the multicenter prospective Canadian Cohort Obstructive Lung Disease study between 2009 and 2015 underwent CT imaging and analysis. Established CT measurements included: tracheal index (TI), defined as the smallest ratio of coronal-to-sagittal trachea diameter, low attenuation areas below -950 HU, and wall thickness of a theoretical 10-mm airway. Trachea surface roughness shape (SR Results: A total of 1253 participants (mean age, 66 ± 10 years; 727 men) from 9 centers were investigated: Conclusion: Increased trachea surface shape roughness is independently associated with worse airflow and increased symptom burden in COPD.
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