ArticleFrontiers in genetics2025
Identification of platelet function-related genes in STEMI patients.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: ST-elevation myocardial infarction (STEMI) is characterized by extensive myocardial necrosis due to acute and severe ischemia, with platelets playing a key role in its pathogenesis. This study aimed to identify platelet function-related biomarkers in STEMI patients. Methods: The GSE59867 dataset, including STEMI patients and controls, was analyzed to identify differentially expressed genes (DEGs) using the limma R package. Platelet function-related DEGs (DEPRGs) were obtained by intersecting DEGs with platelet-related genes. Gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were performed, and a protein-protein interaction (PPI) network was constructed using STRING, followed by identification of hub genes via Cytohubba. The diagnostic value of these genes was evaluated through receiver operating characteristic (ROC) analysis, and further expression validation along with ROC validation was conducted in the GSE123342 dataset. Additionally, gene expression was validated by quantitative real-time polymerase chain reaction (RT-qPCR) in peripheral blood from STEMI patients and cardiac tissue from STEMI mouse models. Results: A total of 245 DEPRGs were identified; enrichment analyses revealed their primary involvement in hemostasis, coagulation, and platelet activation (adjusted Conclusion: This study identified two platelet function-related genes, MAPK3 and GRB2, as potential biomarkers for STEMI, demonstrating high clinical relevance and diagnostic value.
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