Evidence map›Paper›PMID 41059121›Full record

ArticleChemical science2025

A simple epoxide modification strategy to construct amino-functional poly(2-oxazoline) mRNA delivery vectors.

Kuncheng Lv, Yibo Qi, Hanqin Zhao, Yuyan Zhang, Ziyue An, Sheng Ma, Wantong Song

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Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kuncheng LvState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Yibo QiState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Hanqin ZhaoState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Yuyan ZhangState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Ziyue AnState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Sheng MaState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.
Wantong SongState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 China wtsong@ciac.ac.cn.ORCID https://orcid.org/0000-0002-4564-9917

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Messenger RNA (mRNA) delivery vectors are pivotal in the realm of vaccines and gene therapy. While polymer-based delivery vectors have garnered growing interest owing to their tunable structures and favorable biocompatibility, achieving high delivery efficiency remains a critical challenge. Poly(2-oxazoline) (POx) emerges as a promising candidate in biomedicine, yet its exploration in mRNA delivery is nascent. Herein, we engineered poly[2-(5-aminopentyl)-2-oxazoline]-based (PAmOx) polymers as efficient mRNA delivery vectors through a straightforward one-step ring-opening reaction between the amino group on the PAmOx and the epoxide molecules. We conducted a systematic examination of how the degree of polymerization and the nature of grafted epoxide molecules influence mRNA delivery efficiency.

Identifiers

PMID41059121
PMCPMC12498246

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