ArticleFrontiers in medical technology2025
Feasibility analysis of automated cleaning in biopharmaceutical production using cleaning-in-place concepts from food production.
Article in Frontiers in medical technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
In biopharmaceutical production involving cells, cell-derived products, or tissues, the cleaning of surfaces that come into direct or indirect contact with the product is currently performed mostly by hand as the initial step in decontamination. This manual approach leads to production inefficiencies, reduced reproducibility of decontamination processes, and product losses. In food production, automated processes are preferred for the decontamination of interior product contact surfaces. This article studies the feasibility of adapting the automated cleaning-in-place concepts used in the food industry to biopharmaceutical production. The focus is on spray cleaning processes and validation by cleaning simulation. An existing automated cell production platform is used as a case study for validation. The results indicate that modifying an existing platform to support cleaning-in-place presents significant challenges. However, the article outlines general design guidelines for developing new biopharmaceutical production platforms that can accommodate automated cleaning.
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