ArticleCureus2025
Depression and Anxiety as Predictors of Quality of Life in Osteoarthritis Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Osteoarthritis and depression a bidirectional TwoSample Mendelian randomization study on genetic causal association.BMC musculoskeletal disorders · 2026Article
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12 authors.
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Abstract
backgroundOsteoarthritis (OA) is among the most common chronic joint disorders, which not only causes pain and disability, but also adversely impacts the psychological health and the quality of life (QoL). Depression and anxiety are commonly reported in OA patients, but their use as predictors of QoL has not been fully explored in Pakistan. The purpose of this study was to investigate whether depression and anxiety have a predictive effect on QoL in OA patients.
methodsA cross-sectional study was conducted between July and August 2025 among 300 adult OA patients recruited through community health centers, outpatient clinics in Sargodha and Lahore, Pakistan, and orthopaedic departments. The tools used to collect data were a structured questionnaire, consisting of the Hospital Anxiety and Depression Scale (HADS) and the Short Form-36 Health Survey (SF-36). Descriptive statistics, Pearson correlation, independent t-tests, one-way ANOVA, chi-square tests, and multiple linear regression were used to evaluate relationships between psychological and QoL.
findingsThe study population consisted primarily of female patients (N = 240, 80%), with half being older than 65 years (N = 150, 50%). There was a significant correlation between anxiety and depression with lower QoL (r = -0.356 and r = -0.482, respectively; p < 0.001). Women were found to have average anxiety and depression and a low QoL score relative to that of men (p < 0.001). Older age was linked to greater depression and anxiety and less QoL (p < 0.001). Regression analysis revealed a significant predictor of poor QoL as depression (β = -0.245, p = 0.001), anxiety (β = -0.145, p = 0.003), older age, female gender, longer duration of disease, location of OA, and current treatment.
conclusionDepression and anxiety became powerful predictors of poor QoL among OA patients, and depression had a more substantial effect. The results emphasise the need to integrate psychological evaluation and care into the regular OA treatment to enhance patient outcomes. Both physical and mental health care should be given on a holistic basis to improve the QoL of this population.
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