Evidence map›Paper›PMID 41058997›Full record

ArticleCell biomaterials2025

Diabetic hyperglycemia-induced glycation regulates tumor vasculature integrity via NF-κB-mediated GM-CSF secretion by tumor cells.

Wenjun Wang, Lauren A Hapach, Paul V Taufalele, Madison E Bates, Yusheng Wu, Cynthia A Reinhart-King

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenjun WangDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Lauren A HapachDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Paul V TaufaleleDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Madison E BatesDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Yusheng WuDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Cynthia A Reinhart-KingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.

Funding

Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Mechanical Regulation of Tumor AngiogenesisR01HL127499 · NHLBI · VANDERBILT UNIVERSITY · PI REINHART-KING, CYNTHIA A. · 2015 to 2019
$2.4M
Diabetes Promotes Breast Tumor via Glycation-Induced Mechanical Changes in ECMK00CA274695 · NCI · HARVARD UNIVERSITY · PI Wenjun Wang · 2024 to 2026
$274k
Matrix stiffness mediated biglycan expression in the tumor vasculatureF31HL154727 · NHLBI · VANDERBILT UNIVERSITY · PI TAUFALELE, PAUL · 2020 to 2022
$129k
Diabetes Mellitus Promotes Breast Tumor Progression via Glycation Mediated Matrix StiffeningF99CA274695 · NCI · VANDERBILT UNIVERSITY · PI WANG, WENJUN · 2022 to 2023
$96k
NCI NIH HHS F99 CA274695NCI NIH HHS K00 CA274695NHLBI NIH HHS F31 HL154727NHLBI NIH HHS R01 HL127499NIDDK NIH HHS T32 DK101003
6 · The paper itself

Abstract

Glycation is recognized for its ability to stiffen collagen matrices through non-enzymatic crosslinking. However, the biological effects of glycation

Indexed as

AGE-RAGEDiabetic hyperglycemiaendothelial barrier functionGM-CSFNF-kBNon-enzymic glycation

Identifiers

PMID41058997
PMCPMC12499372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.