Evidence map›Paper›PMID 41058988›Full record

ArticleFrontiers in nutrition2025

Real-world effect of intermittent calorie-restricted diet on type 2 diabetes remission: a dual-cohort retrospective study.

Zhiyong Xiao, Xinhong Yin, Xihu Lai, Xu Zhou, Yewu Zhang, Dongliang Yang, Ruiyu Wu, Huiqing Wang, Jiali Zhou, Xiao Yang and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhiyong XiaoHorticulture College, Hunan Agricultural University, Changsha, China.
Xinhong YinSchool of Nursing, University of South China, Hengyang, China.
Xihu LaiXincheng Smart Internet Hospital, Chengdu, China.
Xu ZhouHorticulture College, Hunan Agricultural University, Changsha, China.
Yewu ZhangChinese Center for Disease Control and Prevention, Beijing, China.
Dongliang YangDepartment of General Education Courses, Cangzhou Medical College, Cangzhou, China.
Ruiyu WuHorticulture College, Hunan Agricultural University, Changsha, China.
Huiqing WangHepatobiliary and Pancreatic Surgery Department, First Hospital of University of South China, Hengyang, China.
Jiali ZhouHorticulture College, Hunan Agricultural University, Changsha, China.
Xiao YangHorticulture College, Hunan Agricultural University, Changsha, China.
Bin ZhouDepartment of Endocrinology, The Central Hospital of Shaoyang, Shaoyang, China.
Wu LuoHorticulture College, Hunan Agricultural University, Changsha, China.
Xuan ChenHorticulture College, Hunan Agricultural University, Changsha, China.
Dongbo LiuHorticulture College, Hunan Agricultural University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Randomized controlled trials (RCTs) have demonstrated that intermittent calorie-restricted diet (ICR) can lead to diabetes remission. We aimed to assess the diabetes remission with ICR among patients with type 2 diabetes (T2D) in real-world settings. Materials and methods: We performed a retrospective, dual-cohort study (January 2022-July 2023) using real-world data from Chinese patients with T2D. The ICR cohort consisted of 1,069 patients following an intermittent calorie-restricted diet, while the control cohort consisted of 1,099 patients receiving Dietary Guidelines for Diabetes in China (2017 Edition). The primary outcome was diabetes remission. Secondary outcomes included reductions in antidiabetic medication use and changes in fasting blood glucose (FBG). Subgroup evaluations for the sensitivity analysis were conducted to further assess outcomes. The study employed a combination of univariate and multivariate analyses, including Linear Mixed-Effects Models (LMM), Generalized Linear Mixed-Effects Models (GLMM), and Cox regression with propensity score-weighted Inverse Probability Weighting (IPW), to evaluate relationships between cohort and outcomes. Results: In real-world settings, the ICR cohort achieved significantly higher remission rates (20% vs. 2%, Conclusion: This study demonstrated the practical efficacy of ICR in achieving diabetes remission. These findings establish dietary interventions as a powerful and viable strategy for T2D remission.

Indexed as

diabetes remissiondietdual-cohort retrospective studyintermittent calorie-restricted dietreal-world

Identifiers

PMID41058988
PMCPMC12497798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.