ArticleSmall science2025
Colloidal Interactions in Simulated Intestinal Fluids: Implications for Oral Drug Delivery at the Nanoscale.
Article in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nanostructured Lipid Carriers as Physicochemical Modulators of Complex Natural Extracts: Release Behavior and Bile-Induced Remodeling in Biorelevant Media.Molecules (Basel, Switzerland) · 2026Article
- Colloidal Interactions in Simulated Intestinal Fluids: Implications for Oral Drug Delivery at the Nanoscale.Small science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral drug delivery remains the most preferred administration route, and new oral delivery concepts continuously arise to enable oral delivery of new therapeutics. This study investigates how colloidal structures in five simulated intestinal fluids (SIFs) with varying bile salt and phospholipid compositions influence drug solubility, nanoparticle aggregation and cytotoxicity, and mucoadhesion of nanoparticles and polymers. For the poorly water-soluble drugs indomethacin and felodipine, colloidal structure size in SIFs varies with solubility, and felodipine's solubility is influenced by the lipid composition. Nanoparticles, including polymersomes and mesoporous silica nanoparticles with different surface charges, are characterized in each medium. Dynamic light scattering reveals three interaction modalities: interaction, aggregation, and combination, depending on nanoparticle type and fluid composition. Additionally, interaction patterns correlate with Caco-2 cell cytotoxicity. Quartz crystal microbalance with dissipation analysis reveals that both particle and polymer interactions with mucin are significantly altered in SIFs. For nanoparticles, mucin interactions differ depending on the type of nanoparticle. For the polymers, polyethylene oxide completely loses mucin interaction in SIFs, while chitosan retains partial mucoadhesion. These findings emphasize the importance of not only studying drug properties, but also cell compatibility and mucoadhesion of polymers and nanoparticles, in physiologically relevant conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.