Evidence map›Paper›PMID 41058706›Full record

ArticleFrontiers in immunology2025

CD8

Roman V Uzhachenko, Salvador González Ochoa, Thanigaivelan Kanagasabai, Harshana Rajakaruna, Menaka C Thounaojam, Maria Teresa P de Aquino, Tanu Rana, Lino Costa, Alexander Terekhov, William H Hofmeister and 6 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. CD74Journal of translational medicine · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roman V Uzhachenko *Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Salvador González Ochoa *Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Thanigaivelan Kanagasabai *Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Harshana RajakarunaThe Office for Research and Innovation, Meharry Medical College, Nashville, TN, United States.
Menaka C ThounaojamDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Maria Teresa P de AquinoDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Tanu RanaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Lino CostaCenter for Laser Applications, University of Tennessee Space Institute, Tullahoma, TN, United States.
Alexander TerekhovCenter for Laser Applications, University of Tennessee Space Institute, Tullahoma, TN, United States.
William H HofmeisterCenter for Laser Applications, University of Tennessee Space Institute, Tullahoma, TN, United States.
Thomas J SayersBasic Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Claude BoyerCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.
Alla V IvanovaDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
J Shawn GoodwinDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.
Anne-Marie Schmitt-VerhulstCentre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.
Anil ShankerDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Tumor antigen-escape variants undermine immunotherapy by subverting lymphocyte effector functions and reshaping tumor-immune dynamics. It is essential to delineate functional interplay within immune networks during tumor progression. We investigated whether homeostatic crosstalk between CD8 Methods: Adoptive CD8 Results and discussion: Pre-tumor D Conclusion: Homeostatic conditioning and effector cooperativity between CD8

Indexed as

CD8-Positive T-LymphocytesCell CommunicationImmunologic SurveillanceKiller Cells, NaturalNeoplasmsTumor EscapeAdoptive TransferAnimalsAntigens, NeoplasmCell Line, TumorHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMonitoring, ImmunologicAntigens, Neoplasmadoptive cell transferantigen-loss variantscancer immunotherapyCD8+ T lymphocytesmembranous tunneling nanotubespreemptive immunosurveillanceT cell–NK cell cooperativitytumor immune escape

Identifiers

PMID41058706
PMCPMC12497863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.