ArticleFrontiers in immunology2025
Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- CoexpressDeconvolve enables reference-free single-cell-resolution deconvolution from spot-based spatial transcriptomics.iScience · 2026Article
- Article
- Multi-omics analysis reveals that Danggui Buxue decoction ameliorates benzene-induced blood deficiency syndrome via the restoration of hematopoietic lineage and remodeling of the immune microenvironment.Chinese medicine · 2026Article
- Metabolomic Profiling of Long-Lived Individuals Reveals a Distinct Subgroup with Cardiovascular Disease and Elevated Butyric Acid Derivatives.Metabolites · 2025Article
- Anti-HER2/neu TCR-T Cells in Action: linking transcriptional signatures, secretomics, andFrontiers in immunology · 2025Article
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Authors and funding
7 authors.
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Abstract
Introduction: Pregnancy is a complex process that requires a tightly regulated immune environment to support fetal development and protect against infections. The main barrier between fetus and mother is a specialized organ, the placenta, where the role of specific immune cell populations remains incompletely understood. Methods: In this work, we used spatial transcriptomics at E12.5 to characterize immune and non-immune cell heterogeneity and spatial organization in the mouse placenta. In addition, we performed murine placental mononuclear cell flow cytometry proteomics, murine placental erythroid cell NanoString bulk transcriptomics, and murine placental erythroid cell LegendPlex secretomics at E12.5 and E19.5 to further analyze the immune landscape in the mouse placenta. We also performed single-cell RNA sequencing of human cord blood erythroid cells for cross-species comparisons. Results: Our results show that erythroid cells constitute the predominant immunoregulatory population in murine placentas, comprising on average 80% and 40% of the placental mononuclear cells at E12.5 and E19.5, respectively, expressing Discussion: These results indicate that erythroid cells may act as potent regulators of immunity in murine placentas due to their vast number and repertoire of immunoregulatory molecules, shaping the immune landscape through diverse immunoregulatory mechanisms.
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