Evidence map›Paper›PMID 41058689›Full record

ArticleFrontiers in immunology2025

Preclinical

Shea K Roe, Bo Zheng, Sunita Gulati, Caroline Genco, Sanjay Ram, Paola Massari

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shea K RoeDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Bo ZhengDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Sunita GulatiDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Caroline GencoDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Sanjay RamDivision of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Paola MassariDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.

Funding

Novel vaccine antigens against N. gonorrhoeaeR01AI166537 · NIAID · TUFTS UNIVERSITY BOSTON · PI Paola Massari · 2022 to 2026
$2.2M
NIAID NIH HHS R01 AI166537
6 · The paper itself

Abstract

Background: Methods: In this study, we expanded the immunological characterization of three targets, NGO0690, NGO0948 and Csp (copper storage protein, previously called NGO1701) to include analysis of their efficacy in a mouse model of gonococcal vaginal infection when combined as a trivalent subunit vaccine and adjuvanted with Alum and MPLA. Results: We reported induction of systemic and mucosal antibody responses, serum bactericidal activity against heterologous Discussion: Overall, our results suggested that the rational design of our multi-antigen subunit vaccines holds translational potential for enhancing broadly protective immune responses and protection against

Indexed as

Antigens, BacterialBacterial VaccinesGonorrheaNeisseria gonorrhoeaeAnimalsAntibodies, BacterialDisease Models, AnimalFemaleHumansImmunoglobulin GMaleMiceAntibodies, BacterialAntigens, BacterialBacterial VaccinesImmunoglobulin Gbactericidal antibodiescombination vaccinegonorrheamouse modelprotection

Identifiers

PMID41058689
PMCPMC12497722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.