Evidence map›Paper›PMID 41058677›Full record

ReviewEuropean heart journal. Imaging methods and practice2025

Myocardial active strain energy density and contractance: novel prognostic tools for left ventricular function and cardiovascular risk.

David H MacIver, Henggui Zhang, David Oxborough, Steffen E Petersen, Nay Aung

Abstract readReview
In one paragraph

Review in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The 'myocardial work index' does not measure myocardial work.European heart journal. Imaging methods and practice · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David H MacIverBiological Physics Group, Department of Astronomy and Physics, University of Manchester, Manchester M13 9PL, UK.ORCID https://orcid.org/0000-0002-5139-9029
Henggui ZhangBiological Physics Group, Department of Astronomy and Physics, University of Manchester, Manchester M13 9PL, UK.
David OxboroughResearch Institute for Sports and Exercise Science, Liverpool John Moores University, Liverpool WA8 3BN, UK.ORCID https://orcid.org/0000-0002-1334-3286
Steffen E PetersenWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.
Nay AungWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.ORCID https://orcid.org/0000-0001-5095-1611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial active strain energy density (MASED), also known as contractance, is a novel measure of myocardial contractile function, defined by the area within the stress-strain loop; it quantifies the energy per unit volume of myocardium used to perform work. MASED applies the principle of strain energy density, which is grounded in engineering science, to cardiac tissue. Using cardiovascular magnetic resonance imaging, we demonstrate that global longitudinal active strain energy density (GLASED), a subtype of MASED, provides superior predictive value compared to conventional metrics such as ejection fraction and global longitudinal strain in predicting mortality among patients with hypertensive heart disease, dilated cardiomyopathy, and amyloid heart disease (

Indexed as

contractancecontractile functioncontractilityenergyheart failurestroke worksystolic function

Identifiers

PMID41058677
PMCPMC12499770

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.