Multi-omics pan-cancer profiling of CDK2 and

Cancer is a complex disease characterized by uncontrolled cell proliferation, often driven by dysregulated cyclin-dependent kinases (CDKs), particularly CDK2, which plays a crucial role in cell cycle progression. Aberrant CDK2 activity is associated with tumor growth and resistance to therapy, making CDK2 a promising therapeutic target. The main focus of this research is to integrate the multi-omics-based pan-cancer analysis of CDK2 to identify novel plant-derived inhibitors, bridging the prognostic and therapeutic relevance of CDK2 across various cancer types. In this study, to evaluate CDK2's expression, prognostic behavior, genetic alterations, and immune infiltrations, we performed pan-cancer analysis. The oncogenic analysis showed that CDK2 is significantly overexpressed in multiple tumor types and, in some cancers, which correlated with poor overall and disease-free survival, indicating its potential as a context-dependent prognostic biomarker. The involvement of CDK2 in key cell cycle and oncogenic pathways was investigated, highlighting its centrality in tumor proliferation networks. Additionally, cheminformatics and machine learning approaches were applied to screen phytocompounds from six medicinal plants, and the top phytocompounds (>pIC