ArticleRSC advances2025
Polyacrylamide functionalized polysaccharide based nanocomposite semi-interpenetrating polymeric network hydrogel for pH-responsive controlled release of a model neuroprotective drug.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Progress on Natural Polysaccharide Hydrogels in the Diagnosis and Treatment of Colorectal Cancer.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of advanced drug delivery systems with enhanced stability, controlled release, and biocompatibility is critical for effective neuroprotective therapies. Here, we report a polyacrylamide-functionalized polysaccharide-based nanocomposite semi-interpenetrating polymer network (semi-IPN) hydrogel designed for pH-responsive delivery of the neuroprotective agent citicoline. The semi-IPN structure provides enhanced mechanical strength and tunable swelling, enabling precise and sustained pH-responsive drug release while minimizing burst effects. SEM analysis revealed a porous microstructure that facilitates efficient drug loading and diffusion, and XRD confirmed a semi-crystalline architecture contributing to mechanical stability. Cytotoxicity studies using 3T3 fibroblasts demonstrated excellent biocompatibility, with proliferation comparable to the control. Collectively, these results demonstrate that the developed hydrogel combines robust mechanical properties, tunable swelling, and controlled drug release, representing a promising platform for targeted and effective neuroprotective therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.