Evidence map›Paper›PMID 41058626›Full record

ArticleFrontiers in medicine2025

Impact of hand grip strength reduce on health related quality of life in patients with transfusion-dependent thalassemia insights from the SF-36 survey: a cross-sectional analysis.

Mustafa Duran, Nermin Keni Begendi, Sinan Kazan, Hamza Sümter, Nigar Abdullayeva, Yusuf Ulusoy, Mehmet Enes Süzek, Nur Akad Soyer

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mustafa DuranDivision of Hematology, Department of Internal Medicine, School of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar, Türkiye.
Nermin Keni BegendiDivision of Hematology, Department of Internal Medicine, School of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar, Türkiye.
Sinan KazanDivision of Nephrology, Department of Internal Medicine, School of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar, Türkiye.
Hamza SümterIstanbul Training and Research Hospital, Istanbul, Türkiye.
Nigar AbdullayevaDepartment of Hematology, Faculty of Medicine, Ege University, Izmir, Türkiye.
Yusuf UlusoyDepartment of Hematology, Başakşehir Çam and Sakura City Hospital, Istanbul, Türkiye.
Mehmet Enes SüzekDepartment of Internal Medicine, School of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar, Türkiye.
Nur Akad SoyerDepartment of Hematology, Faculty of Medicine, Ege University, Izmir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Thalassemias negatively impact health-related quality of life (HQoL) due to chronic anemia and complications from regular transfusions. This study aimed to investigate the effects of hand grip strength loss on QoL in patients with transfusion-dependent thalassemia (TDT) via the Short Form-36 (SF-36) health survey. Patients and methods: A cross-sectional study included 47 patients with transfusion-dependent thalassemia (TDT) and a group of healthy controls. Hand grip strength was assessed via a digital handgrip dynamometer. HQoL was evaluated through the SF-36 survey, which includes physical and mental health subdomains. Correlations between dominant arm strength and SF-36 subdomain scores were analyzed. Results: Compared with healthy controls, TDT patients presented significantly lower dominant arm muscle strength ( Conclusion: In patients with TDT, reduced handgrip strength was significantly associated with lower health-related quality of life. These findings suggest that handgrip strength may serve as a simple, non-invasive marker of overall well-being in this population. Addressing muscle strength alongside conventional management may help improve both physical and psychosocial outcomes in TDT patients.

Indexed as

anemiairon overloadmuscle strengthSF-36transfusion-dependent thalassemia

Identifiers

PMID41058626
PMCPMC12497809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.