Evidence map›Paper›PMID 41058617›Full record

ArticleFrontiers in medicine2025

Canonical correlation analysis on the association between pulmonary function and obesity in early-onset COPD: CT-based body composition analysis.

Jiaru Shi, Tianye Li, Zhenghao Chen, Luoman Su, Qiongyan Wu, Hongjun Zhao, Chengshui Chen

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiaru ShiKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tianye LiKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhenghao ChenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Luoman SuKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qiongyan WuKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Hongjun ZhaoDepartment of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Chengshui ChenKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While body composition impacts pulmonary function, the differential effects of visceral (VAT) vs. subcutaneous adipose tissue (SAT) in early-onset COPD remain unquantified. Objective: To elucidate the relationship between obesity patterns and pulmonary function in early-onset COPD versus non-COPD populations, focusing on body mass index (BMI), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) distribution. Methods: This retrospective cohort study analyzed 290 patients (144 early-onset COPD, 146 non-COPD) aged 20-50 years. Body composition (BMI, SAT, VAT) was quantified via CT at the L1 vertebral level. Pulmonary function was assessed by bronchodilator responsiveness testing (FEV₁/FVC, MEF₇₅, MEF₅₀, MEF₂₅). Canonical correlation analysis (CCA) was used to evaluate the multidimensional associations between body composition and pulmonary function. Results: Canonical correlation analysis revealed distinct multidimensional relationships between body composition and pulmonary function across study cohorts ( Conclusion: In summary, early-onset COPD patients with elevated BMI and VAT but reduced SAT exhibited improved pulmonary function across most parameters. This enhancement was not observed in MEF

Indexed as

body compositionchronic obstructive pulmonary diseaseearly-onset COPDobesitypulmonary function

Identifiers

PMID41058617
PMCPMC12497633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.