Evidence map›Paper›PMID 41058570›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Life-Course Burden of Blood Pressure Is Associated With Midlife Cognitive Function.

Wei Chen, Changwei Li, Ruiyuan Zhang, Zhijie Huang, Shengxu Li, Ileana De Anda-Duran, Owen T Carmichael, Hao Ma, Xuan Wang, Tanika N Kelly and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei ChenDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).ORCID 0000-0003-1566-7943
Changwei LiDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX (C.L., J.H., L.A.B).ORCID 0000-0002-9203-304X
Ruiyuan ZhangDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).ORCID 0000-0002-4639-3300
Zhijie HuangDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).
Shengxu LiChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN (S.L.).
Ileana De Anda-DuranDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).ORCID 0000-0003-3629-9465
Owen T CarmichaelPennington Biomedical Research Center, Baton Rouge, LA (O.T.C.).ORCID 0000-0002-0576-0047
Hao MaDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).
Xuan WangDepartment of Epidemiology, Tulane University, New Orleans, LA (W.C., R.Z., Z.H., I.D.A.-D., H.M., X.W.).
Tanika N KellyDepartment of Epidemiology, University of Illinois Chicago, IL (T.N.K.).ORCID 0000-0002-7348-4451
Jiang HeDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX (C.L., J.H., L.A.B).ORCID 0000-0002-8286-9652
Lydia A BazzanoDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX (C.L., J.H., L.A.B).ORCID 0000-0002-8958-1352

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Tony Y. Hu · 2016 to 2026
$25.3M
Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's DementiaR01AG077497 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2022 to 2025
$11.9M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain HealthR01AG077000 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Lydia Bazzano, OWEN T. CARMICHAEL · 2022 to 2026
$3.6M
Genetic Predisposition to Elevated Blood Pressure and Midlife Cognitive Function: Exploring the Impact of Lifespan Risk Factors and Polygenic Risk ScoresK08AG086588 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI Ileana De Anda-Duran · 2025 to 2026
$306k
NHLBI NIH HHS R01 HL121230NIA NIH HHS K08 AG086588NIA NIH HHS R01 AG062309NIA NIH HHS R01 AG077000NIA NIH HHS R01 AG077497NIA NIH HHS RF1 AG041200NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

backgroundWe aimed to examine relationships between cumulative life-course burdens and trajectories of cardiovascular risk factors and midlife cognitive function in a longitudinal cohort of the Bogalusa Heart Study.

methodsThe study cohort consisted of 912 participants who had cognitive function measured in middle age, and body mass index, blood pressure (BP), atherogenic index of plasma, and LDLC (low-density lipoprotein cholesterol) examined 4 to 15 times from childhood to adulthood. Total and incremental area under the curve (AUC) were calculated as a measure of long-term burden and trend of risk factors, respectively.

resultsTrajectories of systolic BP were separated markedly around 25 to 45 years of age, with the group below the median of cognition score having higher levels of systolic BP than the group above the median. Adjusting for covariates, midlife cognitive function was associated with total and incremental AUCs of systolic BP. Standardized regression coefficients were -0.086 (95% CI, -0.161 to -0.010;

conclusionsData suggest that the impact of exposure to high BP on the brain accumulates across the lifespan. A life-course approach is superior in risk assessment for cognitive decline and dementia.

Indexed as

Blood PressureCognitionHypertensionAdultBody Mass IndexFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk Factorsblood pressurebody mass indexcognitiondementiaobesity

Identifiers

PMID41058570
PMCPMC12755962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.