Evidence map›Paper›PMID 41058189›Full record

ArticleAdvanced healthcare materials2026

Natural Sweetener Stevioside-Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia.

Junying Zhang, Tianyu Shao, Hailiang Li, Luying Zhu, Lamyaa Albakr, Nial J Wheate, Lifeng Kang, Chungyong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junying ZhangDepartment of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.
Tianyu ShaoDepartment of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.
Hailiang LiDepartment of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.
Luying ZhuDepartment of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China.
Lamyaa AlbakrSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Pharmacy and Bank Building A15, Sydney, New South Wales, 2006, Australia.
Nial J WheateSchool of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales, 2109, Australia.
Lifeng KangSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Pharmacy and Bank Building A15, Sydney, New South Wales, 2006, Australia.ORCID https://orcid.org/0000-0002-1676-7607
Chungyong WuDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China.

Funding

National Natural Science Foundation of China 81473357National Natural Science Foundation of China 82473889
6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is a prevalent form of non-scarring hair loss. Standard treatments, which include minoxidil (MXD) tincture and foam, face challenges due to MXD's water insolubility and poor skin permeability. The result is extended treatment duration and reduced therapeutic effectiveness. This study utilized stevioside (STV), a natural sweetener derived from the Stevia plant, as a novel solubilizing excipient and microneedle (MN) material. A solid dispersion of STV with insoluble drugs is developed and molded into an MN patch. STV significantly increased MXD's solubility to 47 mg mL

Indexed as

AlopeciaDiterpenes, KauraneGlucosidesMinoxidilSweetening AgentsAnimalsDrug LiberationHair FollicleMaleMiceMicellesNeedlesSkin AbsorptionSolubilitySwineDiterpenes, KauraneGlucosidesMicellesMinoxidilsteviosideSweetening Agentsdissolving microneedlesminoxidilsolid dispersionsolubilizationstevioside

Identifiers

PMID41058189
PMCPMC12805625

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.