Observational studyBrain and behavior2025
Effect of Preinfection Health Status on COVID-19 Severity and Cognitive Function.
Observational study in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Effect of Preinfection Health Status on COVID-19 Severity and Cognitive Function.Brain and behavior · 2025Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThis observational cohort study investigates how infection health factors influence COVID-19 severity and cognitive outcomes. We collected preinfection data from hospitalized COVID-19 patients, including demographic information and baseline health conditions prior to diagnosis, and examined their associations with hospitalization duration and cognitive function assessed after infection.
methodsData were obtained from Hui Ya Hospital, The First Affiliated Hospital, Sun Yat-sen University, China. The study included confirmed COVID-19 patients requiring hospitalization. Among the 147 collected cases, two were excluded due to missing data, leaving a final sample of 145 patients. The Montreal Cognitive Assessment (MoCA), which evaluates global cognitive function with a total score of 0-30, was used to assess cognitive function, while hospitalization duration and routine clinical examinations were analyzed as indicators of disease severity. Additionally, the SF-12v2 score reflecting Health-Related Quality of Life was used to evaluate patients' overall health status. Statistical analyses were conducted to identify preinfection factors associated with COVID-19 outcomes.
resultsPreinfection baseline health status was significantly correlated with both hospitalization duration (p < 0.0001, 95% CI [-0.47, -0.16]) and MoCA scores (p = 0.0001, 95% CI [0.15, 0.46]). Patients with better preinfection health conditions experienced shorter hospital stays and demonstrated better cognitive function postinfection.
conclusionOur findings indicate that preinfection baseline health conditions play a crucial role in determining both the severity of COVID-19 and postinfection cognitive function. Specifically, impairments were more pronounced in the visuospatial, naming, attention, calculation, language, and memory domains. Additionally, our results suggest a potential link between COVID-19 outcomes and patients' preexisting underlying diseases.
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