ArticleMolecular imaging and radionuclide therapy2025
Radiation-induced Xerostomia: Evaluation with
Article in Molecular imaging and radionuclide therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Objectives: To investigate the relationship between radiation dose, metabolic changes in the salivary glands assessed by Methods: We retrospectively analyzed 107 patients treated with intensity-modulated RT or volumetric modulated arc therapy for head and neck malignancies. Clinical xerostomia severity was evaluated at the time of post-treatment PET/CT. Mean gland doses and dose-volume parameters (V10-V50) were extracted from treatment plans. Metabolic changes were evaluated by Results: Moderate-to-severe xerostomia occurred in 63.6% of patients. Both higher T and N stage were significantly associated with greater xerostomia severity (p<0.05). Patients with nodal metastases on pretreatment PET/CT demonstrated a higher prevalence of xerostomia. Dose-volume parameters (V10-V30 for parotids, V50 for submandibular glands) were significantly correlated with symptom severity. Conclusion: Despite the use of advanced RT techniques, xerostomia remains a frequent toxicity.
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