ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Assessment and detection of nucleotide excision repair capability in human cells: a critical review of current functional methods.Molecular biology reports · 2026Review
- Fluorescent reporter assay reveals ribonucleotides promote mismatch correction in vivo.Nucleic acids research · 2026Article
- Functional Profiling of DNA Repair Pathways in Lung Cancer Patients Uncovers Radiotherapy-Induced and Cancer-Associated Alterations in Oxidative Lesion Repair.medRxiv : the preprint server for health sciences · 2026Article
- Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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8 authors.
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Abstract
Rare genetic DNA repair deficiency syndromes can cause immunodeficiency, neurological disorders, and cancer. In the general population, inter-individual variation in DNA repair capacity (DRC) influences susceptibility to cancer and age-related diseases. Genome-wide association studies and functional analyses indicate that defects in multiple DNA repair pathways jointly increase disease risk, but previous technologies do not permit comprehensive population-level analysis. Fluorescence multiplex host cell reactivation (FM-HCR) assays now allow direct quantification of DRC across six major DNA repair pathways. DRC is assessed in phytohemagglutinin-stimulated primary lymphocytes from 56 healthy individuals, with reproducibility validated in 10 individuals across up to five independent blood draws. Generalized analytical pipelines are developed to systematically correct batch effects and experimental confounders. Significant inter-individual variation is observed across 10 reporter assays measuring distinct repair processes, with weak correlations between pathways suggesting independent disease susceptibility contribution. A complementary pipeline analyzing comet repair kinetics allows integration with previously reported comet data from the same individuals. This study underscores the sensitivity of FM-HCR assays in detecting subtle biological differences and establishes standardized methodologies for population research. The findings and open-source tools advance precision health by enabling comprehensive exploration of genetic and environmental determinants of DRC, supporting targeted interventions to maintain genomic integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.