ArticleVeterinary research2025
Investigating the functional capacity of porcine uterine natural killer cells during a porcine reproductive and respiratory syndrome virus infection of pregnant gilts.
Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Uterine natural killer (uNK) cells play crucial roles in pregnancy, impacting maternal-fetal immune tolerance, angiogenesis, and immune responses. While extensively studied in humans and mice, porcine uNK cells' functional properties remain relatively underexplored in both healthy uterine environments, as well as during viral infection. This study examined the functional properties of porcine uNK cells isolated from the maternal endometrium (ME) and fetal placenta (FP) in late gestation, comparing healthy gilts to those experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV), one of the most economically damaging reproductive viruses of the swine industry. Flow cytometry analyses identified three uNK cell subsets based on NKp46 expression to assess subpopulation frequencies and functional variations. Results showed that PRRSV infection did not significantly alter the total NK cell counts but affected NK cell proliferation. NKp46
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