ReviewTropical diseases, travel medicine and vaccines2025
Costs, delivery strategies and implementation challenges for malaria vaccines: a rapid review of literature.
Review in Tropical diseases, travel medicine and vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe burden of malaria remains high, particularly in sub-Saharan Africa, where it accounts for over 200 million cases annually. Vaccination is the latest tool in the armamentarium to prevent malaria. Although a couple of malaria vaccines have been deployed in some countries, gaps in knowledge about their delivery, cost, and effectiveness remain. This rapid review synthesized evidence on issues on malaria vaccines implementation to inform strategies for optimising their accessibility.
methodsA comprehensive search of PubMed, Google Scholar, and Cochrane Library was conducted to identify studies that examined malaria vaccine delivery mechanisms, costs, and logistical challenges from 2000 to 2024. The articles underwent duplicates removal, title/abstract screening, and full-text review. Eligible studies included those on currently approved and emerging malaria vaccines. Data were extracted systematically and synthesized descriptively.
resultsThirty studies met the inclusion criteria, with 21(%) conducted in Africa. RTS, S/AS01 was the most commonly reported vaccine (n = 23, 76.67%), with reported efficacy rates of 30% - 75%. Cost-effectiveness estimates for the vaccines varied from $20 - $50 per DALY averted, but higher costs were reported in some settings. Delivery strategies largely involved routine immunization (n = 12, 40%), although innovative methods, including drones, showed promise in one study. Key barriers were logistical constraints, community acceptance, and healthcare infrastructure limitations.
conclusionsThe findings highlighted delivery and cost-effectiveness challenges for malaria vaccination. Ways and means of reducing the costs and improving the effectiveness of different sustainable malaria vaccine delivery strategies, especially in remote and underserved communities should be developed. Limitations of this rapid review include restriction to English-language studies, exclusion of grey literature, and variability in study designs, which may have limited comprehensiveness and comparability of findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.