Trial reportBMC complementary medicine and therapies2025
The effect of Citrus aurantium inhalation aromatherapy on chemotherapy-induced nausea and vomiting in breast cancer patients: a randomized controlled trial.
Trial report in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Essential oil-based interventions for chemotherapy-induced nausea and vomiting in women with breast cancer: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer (BC) is the second most common cancer globally and the most prevalent among women. Chemotherapy, a primary treatment, frequently induces distressing side effects like nausea and vomiting. This study evaluated the efficacy of Citrus aurantium inhalation aromatherapy in reducing chemotherapy-induced nausea and vomiting (CINV) in women with BC.
methodsIn this CONSORT-compliant parallel-group randomized controlled trial (registered at IRCT: 20240305061177N1), 92 BC patients at Motahari Clinic were randomly allocated (between April to August 2024) to an aromatherapy group (n = 46) or a control group (n = 46). Alongside standard antiemetic medications, the aromatherapy group inhaled two drops of C. aurantium essential oil applied to the philtrum, while the control group received sunflower oil. The Rhodes Index assessed nausea, vomiting, and retching over five days.
resultsSignificant reductions in mean total scores for nausea, vomiting, and retching were observed in the aromatherapy group compared to the control group from days 3 to 5 (P < 0.05), with no significant differences on days 1 and 2. Total symptom scores significantly decreased from Day 1 to Day 5 in the aromatherapy group while the control group showed no change.
conclusionC. aurantium aromatherapy significantly alleviated CINV during the delayed phase (days 3-5). Given its safety, affordability, and accessibility, this intervention offers a promising complementary approach for managing CINV in BC patients.
trial registrationThis trial was registered with the Iranian Registry of Clinical Trials (IRCT20240305061177N1, march 17, 2024).
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