ArticleNature immunology2025
Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire.
Erratum issuedAbstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Low ZAP70 expression drives neonatal TNature immunology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Brian D Stadinski *Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-3831-6751
Elizabeth A Mills *Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-7847-624X
Preston A HumphriesDivision of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8736-6432
Sarah B ClevelandDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9536-1789
Parker DowDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Kaoru MurakamiDivision of Molecular Psychoimmunology, Institute for Genetic Medicine and Institute for Vaccine Research and Development, Hokkaido University, Sapporo, Japan.
Yue Ru LiImmunology Department, University of Toronto, Toronto, Ontario, Canada.
Masaaki MurakamiDivision of Molecular Psychoimmunology, Institute for Genetic Medicine and Institute for Vaccine Research and Development, Hokkaido University, Sapporo, Japan.
Masahiro OnoDepartment of Life Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-9284-7326
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6446-9102
Gerald P MorrisDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Juan Carlos Zúñiga-PflückerImmunology Department, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2538-3178
Robert A CampbellDepartment of Emergency Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0027-694X
Eric R GriffithsSection of Congenital Heart Surgery, University of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.
Eric S HusebyDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA. eric.huseby@umassmed.edu.ORCID http://orcid.org/0000-0001-5423-2542
Wan-Lin LoDivision of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. wan-lin.lo@path.utah.edu.ORCID http://orcid.org/0000-0002-9074-6847
Funding
DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007491 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI James Alan Gagnon, Kristen M Kwan · 1995 to 2026
$8.0MTRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5MTCR signaling control of thymic Treg selection and immune homeostasisR01AI143976 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BERG, LESLIE JOAN, HUSEBY, ERIC S · 2020 to 2024
$2.9MUnmasking the Immunomodulatory Roles of CD7 SignalingR01AI175301 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Wan-Lin Lo · 2023 to 2026
$2.2MPlatelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke InjuryR01HL163019 · NHLBI · WASHINGTON UNIVERSITY · PI CAMPBELL, ROBERT A · 2022 to 2025
$2.2MHUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITROR01HL160808 · NHLBI · WASHINGTON UNIVERSITY · PI CAMPBELL, ROBERT A · 2022 to 2025
$2.1MDual TCR Expression Effects on Alloreactivity and TransplantationR01AI151293 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MORRIS, GERALD PATRICK · 2020 to 2024
$1.9MInfluence of MHC-II polymorphisms on autoimmune T cell repertoire development and functionR01DK138198 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric S Huseby · 2024 to 2026
$1.6MGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-192050Japan Agency for Medical Research and Development (AMED) JP21zf0127004Japan Agency for Medical Research and Development (AMED) JP23gm1910005Japan Agency for Medical Research and Development (AMED) JP243fa627005NHLBI NIH HHS R01 HL160808NHLBI NIH HHS R01 HL163019NIAID NIH HHS R01 AI143976NIAID NIH HHS R01 AI151293NIAID NIH HHS R01 AI175301NIAID NIH HHS T32 AI007349NICHD NIH HHS T32 HD007491NIDDK NIH HHS R01 DK138198U of U | School of Medicine (University of Utah School of Medicine) Department of Pathology Career Development fundU of U | School of Medicine (University of Utah School of Medicine) Department of Pathology StartupU.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD007491U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL160808U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL163019U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI143976U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI151293U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI175301U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK138198
Abstract
The Foxp3⁺ regulatory T (T
Indexed as
ThymocytesThymus GlandT-Lymphocytes, RegulatoryZAP-70 Protein-Tyrosine KinaseAdaptor Proteins, Signal TransducingAge FactorsAnimalsAnimals, NewbornCalcium SignalingCell DifferentiationClonal DeletionForkhead Transcription FactorsHumansMembrane ProteinsMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingForkhead Transcription FactorsLat protein, mouseMembrane ProteinsPhospholipase C gammaZap70 protein, mouseZAP-70 Protein-Tyrosine Kinase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.