Evidence map›Paper›PMID 41057626›Full record

ArticleCommunications biology2025

Optogenetic induction of subcellular Ca

Yujing Zhang, Jing Yu-Strzelczyk, Dmitri Sisario, Rebecca Holzapfel, Zoltan Nagy, Congfeng Xu, Chengxing Shen, Georg Nagel, Shiqiang Gao, Markus Bender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yujing ZhangInstitute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany.
Jing Yu-StrzelczykDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany.
Dmitri SisarioInstitute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany.
Rebecca HolzapfelInstitute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany.
Zoltan NagyInstitute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany.
Congfeng XuDepartment of Cardiology, Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-8009-4865
Chengxing ShenDepartment of Cardiology, Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Georg NagelDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-8174-8712
Shiqiang GaoDepartment of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany. gao.shiqiang@uni-wuerzburg.de.ORCID http://orcid.org/0000-0001-6190-9443
Markus BenderInstitute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany. bender_m1@ukw.de.ORCID http://orcid.org/0000-0002-2381-116X

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 452622672Deutsche Forschungsgemeinschaft (German Research Foundation) 525167920Deutsche Forschungsgemeinschaft (German Research Foundation) TR240 374031971
6 · The paper itself

Abstract

Calcium signaling is crucial across various cell types, but its spatiotemporal dynamics remain difficult to study due to limited methods. Optogenetics, with its high precision, can address this challenge. In this study, we introduced the channelrhodopsin variant ChR2 XXM2.0, which exhibits high light sensitivity and enhanced Ca

Indexed as

Blood PlateletsCalciumCalcium SignalingChannelrhodopsinsMegakaryocytesOptogeneticsAnimalsMiceMice, TransgenicCalciumChannelrhodopsins

Identifiers

PMID41057626
PMCPMC12504666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.